The explosive growth of data derived from genomic and post-genomic projects has revolutionized biology and medicine. As a result, a solid foundation in computational biology and bioinformatics is now essential for all practitioners of biological and biomedical research. This course emphasizes both the theory and application of fundamental computer-based approaches to sequence analysis, datamining, integration and interpretation of data related to genes and their function. Using a hands-on problem-based learning approach, students will acquire familiarity with computational tools useful for analysis of the structure, function, and evolution of nucleic acids and proteins.